To specifically assess the correlation between biomarkers in clinical samples and the biomarkers that we identified in mesenchymal cells in vitro, we quantified the serum levels of BDNF; however, those showed an opposite trend possibly because low levels of BDNF have been associated with depression and anxiety, which are quite common in patients with BM [51, 52]. The gene discussed is BDNF; the disease is major depressive disorder.