Finally, the analysis of tissue sections of BM from breast carcinoma suggest that carcinoma cells are highly acidic, as demonstrated by the strong LAMP2 staining [19] in carcinoma cells, and furthermore, that IL8 appeared to be secreted for the most part by the mesenchymal stroma, close to the acidic area of the tumor, rather than by the tumor itself. This evidence concerns the gene LAMP2 and neoplasm.