STAT3 and head and neck squamous cell carcinoma: To investigate the clinical relevance of platinum-induced STAT protein modulation in tumor cells in cancer patients, we analyzed expression of STAT3 in tumors of two cohorts of patients with head and neck squamous cell carcinoma (HNSCC) who had been treated with either cisplatin-based chemo-radiotherapy (n = 65) or radiotherapy alone (n = 32).