Univariate analysis shows that Barcelona Clinic Liver Cancer (BCLC) classification stage (p = 0.001), HBsAg positive (p = 0.003), AFP levels > 400 ng/ml (p = 0.033), tumor size (p = 0.002) and Vascular invasion (p = 0.028) were significantly influence tumor-free survival time (Table 2). Here, AFP is linked to liver cancer.