ZEB1 and breast cancer: Notably, as shown in Figure 4F, we observed that the SD phenotype was less represented (32.0% vs 13.3%), and the AD phenotype was enhanced (17.0% vs 31.3%), after ectopic expression of Ngn3 in ZEB1/231 cells; this demonstrated that ZEB1 is linked to stem cell identity in breast cancer cells, thus at least partially accounting for the downregulation of Ngn3 expression.