One study reported that about 50% of breast tumors showed NR4A1 overexpression; TNF-α-induced NR4A1 expression in MCF-7 ERα-positive breast cancer cells plays an anti-apoptotic role; and ectopic expression of NR4A1 also promotes MCF-7 cell growth [17]. This evidence concerns the gene NR4A1 and breast neoplasm.