In conclusion, our results demonstrate, for the first time that ING5 knockdown induces EMT by activating EGFR/PI3K/Akt and IL-6/STAT3 oncogenic signaling pathways, leading to increased cancer invasion and metastasis, thus proposing a promising role of ING5 in anti-metastasis therapy for lung cancer patients. This evidence concerns the gene AKT1 and cancer.