While some inhibitors of anti-apoptotic proteins (like ABT-263 and ABT-199) show promise in clinical trials for multiple cancers including acute myeloid leukemia and small-cell lung cancer [22, 23], our compound 8 (Comp8, Scheme 1) distinguishes itself in its dual activity to both suppress cancer cells and inhibit PUMA-dependent apoptosis of non-cancerous cells. Here, BBC3 is linked to cancer.