We treated colorectal tumour HCT116 cells transiently overexpressing MPG or XRCC1 (Figure 4A, 4B and 4C) with 5-FU (2.5μM and 5μM) (Figure 4D and 4E) and with TMZ (10μM and 20μM) for 24h and 48h (Figure 4F and 4G). This evidence concerns the gene XRCC1 and colorectal neoplasm.