PKC family members have also been demonstrated to play important roles in pathogenesis of many heart diseases, including heart failure [9, 12], myocardial infarction [13, 14], ischemia-reperfusion injury [15], myocardial hypertrophy [16], dilated cardiomyopathy [17] and diabetic cardiomyopathy [18]. The gene discussed is PRRT2; the disease is heart failure.