When evaluating the relationship between HSF1 and patients’ clinicopathological data, we found that higher expression of HSF1 correlates with lower HCC survival rate (Figure 6D) and this association remains strongly significant after multivariate Cox regression analysis (P < 0.0001; Supplementary Table 2), indicating that HSF1 is an independent prognostic factor for HCC. Here, HSF1 is linked to hepatocellular carcinoma.