To address this issue, a steadily growing amount of work was beginning to handle lung cancer through oncogene-related transformation of normal lung cells, including H-ras [28], K-ras [29], Trp53 and Rb1 [30], PIK3CA, cyclin D1, or a dominant-negative form of LKB1 [31]. The gene discussed is PIK3CA; the disease is lung carcinoma.