E2F3 and neoplasm: However, cytoplasmic and nuclear E2F3 expressions were correlated strongly with the tumor sizes (p=0.021 and p<0.001), clinical stages (p=0.030 and p=0.003), MVI (p=0.002 and p<0.001), and metastatic state (p=0.001 and p=0.016), except for histological grade (Fuhrman grade) (p=0.385 and p=0.028).