E2F3 overexpression in ACHN cells drove the cell cycle from G1 phase into S phase while the HIF-2α knockdown restored the cell into G1 phase, suggesting that E2F3 may promote the proliferation of ccRCC cell lines through the activation of HIF-2α (Figure 4D). The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.