SP1 and acute myeloid leukemia: In addition, both SP1 and MYC knockdown decreased cell proliferation and re-activated PP2A (Figure 3D–3E, Figure 4D-4E, and Supplementary Figures S8D-S8E and S9D-S9E), indicating that these TFs activate the expression of SET, resulting in PP2A inactivation in AML cells.