Other genes belonging to this repressed pro-inflammatory profile but with less intensity were the autophagy and inflammasome component, atg4b, and the SNARE component syntaxin 3, stx3. These results suggest a marked effect of LMWT infection in the transcriptome of microglia and the induction of TNF-α-mediated death signalling controlled by actA gene, which was different from the transcriptional pattern that LMwt induced in macrophages (Figure 4A). The gene discussed is ATG4B; the disease is infection.