Although we recognize the transgenic MAFIA mouse model used in the present study is specific for the CSF-1R+ lineage (CD45+CD11b+GFP+ population composed by monocytes, macrophages, and some cDCs) and no single cell-specific population, it is a valuable tool to uncover a potentially relevant pathway controlling HSV-1 induced nerve regression driven by the elicited innate immune response to infection. Here, PTPRC is linked to infection.