To obtain a complete overview of the entire complement of RNA expression that is altered in Grn deficiency, with a particular focus on transcripts involved in lipid metabolism, we sequenced the mRNA extracted from the brains of 7-month-old Grn+/+, Grn+/−, and Grn−/− mice. The gene discussed is GRN; the disease is hyperinsulinemic hypoglycemia, familial, 4.