Moreover, our RNA-seq data allowed us to quantitatively compare transcriptomic changes in Grn deficiency with a previously reported dataset obtained in Npc1 knockout (Npc1−/−) mouse brains (Figures 5B–5F), revealing selective changes in the expression of lysosomal, immune-related, and lipid-related genes between NPC1 and PGRN deficiency states. This evidence concerns the gene GRN and hyperinsulinemic hypoglycemia, familial, 4.