Collectively, these data are compatible with ELL2 having a role in the UPR and autophagy regulation in MM through its interaction with BiP and ATF6. Importantly, due to the pre-existing ER stress in MM plasma cells, such cells are particularly prone to drug-induced ER stress by, for example, the proteasome inhibitor bortezomib (Obeng et al., 2006). This evidence concerns the gene ATF6 and Miyoshi myopathy.