The experimental results of SSH showed that there were five upregulated lipid metabolism genes including low-density lipoprotein receptor (LDLR), scavenger receptor B (SCARB), HMG-CoA reductase (HMGCR), cholesteryl ester transfer protein (CETP) and ApoB, and one down-regulated lipoprotein lipase (LPL), indicating that HCMV infection directly influenced intercellular lipid metabolism. This evidence concerns the gene LDLR and cytomegalovirus infection.