KCNA5 and pulmonary arterial hypertension: O2-sensitive voltage-gated potassium channels (Kv channels) including Kv1.2, Kv1.5, Kv2.1/9.3, and Kv3.1b in resistance PASMCs play a critical role in the maintenance of ionic homeostasis to modulate membrane potential under hypoxia conditions during PAH development (4,11–17).