IL10 and diabetes mellitus: Although the physiopathology of TB susceptibility in patients with DM remains to be clarified, changes in the immune system have been described, including alterations in the complement pathway in patients with DM [78], increase in type 1 innate cytokines [79, 80], a reduction in the activation of alveolar macrophages [81], and increased IL-10 producing ability [82, 83].