Tie2-expressing monocytes (TEMs) have been found in various human tumors to form tumor blood vessels and promote tumor angiogenesis and growth by paracrine secretion of angiogenic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), and matrix metalloproteinase-9 (MMP-9) [6–8]. The gene discussed is MMP9; the disease is neoplasm.