Hence, in the present study, we developed a dendrimer (PAMAM-DEN)-based cysteamine (PAMAM-DENCYS) analogue that possesses autophagy-inducing and mucolytic properties, and has the potential to rescue ΔF508-CFTR in CF, while also decreasing Pa infection that exacerbates CF lung disease (28). This evidence concerns the gene CFTR and cystic fibrosis.