Our previous work evaluating autoimmune LG inflammation (dacryoadenitis) in a murine model of SS, the non-obese diabetic (NOD) mouse, revealed that increased expression and activity of a lysosomal protease, cathepsin S (CTSS) in the LG paralleled the onset of lymphocytic infiltration [19, 20]; moreover, CTSS was increased not only in LGAC but was secreted in increased amounts into tears of the NOD mice. This evidence concerns the gene CTSS and dacryoadenitis.