In order to identify whether miR-145-5p indeed has a direct interaction with ADD3 and regulates its expression and thus, contributes to liver fibrosis in biliary atresia, we synthesize 4 different lentiviruses, miR-145, miR-145-3p inhibitor, miR-145-5p inhibitor and empty vector without miR-145, respectively. This evidence concerns the gene ADD3 and Hepatic fibrosis.