OPN1SW and Hepatic fibrosis: With regard to the presence of BCP or PC mutations, the A1762T/G1764A variant was identified in 36.7% of patients with grade 1 and 2 liver fibrosis (29/79) and in 81.8% of patients with grade 3 and 4 liver fibrosis (9/11) (p < 0.01); in 76.9% of patients with cirrhosis (10/13) and in 38.1% of patients without cirrhosis (40/105) (p = 0.01).