To investigate the status of downstream mediators in HGF/c-Met signaling pathway by IRCR201 treatment, we evaluated phosphorylation of Akt and Erk1/2 in PBS- or 15 mg/kg IRCR201-treated MKN45 tumor sections through immunohistochemical analysis (Figure 9e,f). The gene discussed is AKT1; the disease is neoplasm.