To determine whether IRCR201 could inhibit the tumor growth of cancer cells with c-Met amplification and constitutively phosphorylate c-Met activity in the absence of HGF, an MKN45 gastric cancer cell line was employed and showed significantly reduced IRCR201-mediated cellular proliferation compared to huOA5D5.v2 (Figure 5c). Here, HGF is linked to neoplasm.