HMOX1 and colorectal adenoma: This compound could induce the nuclear translocation of Nrf2 and the expression of NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) in human colorectal cancer cells (HCT116), and significantly inhibit the development of colorectal adenomas in the azoxymethane (AOM)-dextran sodium sulfate (DSS) mouse model.