NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: The table not only summarizes the main characteristics of cysteine-sparing NOTCH3 missense mutations, but also shows the five criteria required for mutations to be considered potentially pathogenic: type of mutation, typical clinical CADASIL syndrome, diffuse WMH, whole exon analysis, mutations that were not polymorphisms and GOM deposition, and the author.