NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: The aims of this article are to: (1) find data in the literature and in databases relating to cysteine-sparing NOTCH3 missense mutations observed in patients with typical clinical CADASIL syndrome; (2) describe the epidemiological characteristics of these patients; (3) determine whether these mutations could be considered potentially pathogenic.