Therefore, we considered that p.R61W [23], p.R75P [25], p.D80G [27], andp.R213K [33] could be potentially pathogenic mutations, because they were associated with typical clinical CADASIL syndrome and extensive WMH in MRI, the 33 NOTCH3 exons were analyzed and no other potential pathogenic mutations were found; they had an MAF < 0.1% (ExAC, 1000 Genomes Project) (confirming that they are not common polymorphisms) and GOM deposits were observed in the skin biopsy. This evidence concerns the gene NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1.