INS and Insulin resistance: It is well established that visceral and subcutaneous adipose tissue exhibit a depot-specific response to weight gain,8 which is associated with individual metabolic risks.4 In principle, adipocyte size positively correlates with fat mass.41 However, cell size of subcutaneous adipocytes inversely correlates with insulin sensitivity and the rate of weight loss in formerly obese mice.42, 43 Increases in visceral adipocyte size is associated with increased local and systemic inflammation and insulin resistance.44