IFNA1 and Zika virus infectious disease: Mean whole-brain [18F]DPA-714 binding in ZIKV + PBS remained at modest levels at day 6 PI (2.51 ± 0.30 %ID/g, n = 5) and returned to the level of historic PBS controls by day 10 PI suggesting that ZIKV infection in the presence of IFN signaling is sufficient to produce a mild yet transient neuroinflammatory effect measureable by [18F]DPA-714 PET imaging.