C5 and Sepsis: In rodents, sepsis-induced pro-coagulatory activity and synchronic signs of DIC, as indicated by prolonged activated partial thromboplastin time (APTT), reduced platelet count, thrombin-antithrombin (TAT) complexes, D-dimers, and tissue-plasminogen activator (t-PA), are mostly reversed by C5a blockade, resulting in an improved survival rate [102].