Previously, we have established an expression data set of human HCC tumor with adjacent histologically normal liver tissues and the survival information of these patients.11,12 Of the 43 HCC patients analyzed that either expressed low ACSL4 and high GADD45B or high ACSL4 and low GADD45B, we observed a significant difference in the overall and recurrence-free survival of these two groups of patients (Figures 6a and b) using the median expression value of ACSL4 and GADD45B as the cut-off for high and low ACSL4 and GADD45B expression, respectively. The gene discussed is GADD45B; the disease is neoplasm.