For analysis, we used TA-1887, an SGLT2i with selectivity for SGLT2 versus SGLT1, similar to canagliflozin.11, 12 To determine treatment effects, we evaluated db/db mice (also known as Lepr −/− mice) fed a HF diet as a model of severe diabetes and treated them with or without TA-1887. The gene discussed is LEPR; the disease is diabetes mellitus.