Xie et al. studied the effect of Bu-Shen-Yi-Gan-Huo-Xue decoction on gene expression of mouse bone marrow stromal cells into cartilage differentiation and found that the two important related genes Eefmp1 and Mmp3 had significant differences in expression of cartilage metabolism, indicating that the mechanism of Bu-Shen-Yi-Gan-Huo-Xue decoction in the treatment of osteoarthritis may be related to the pathway mediated by EFEMP1 and MMP3 [75]. This evidence concerns the gene MMP3 and osteoarthritis.