FOS and Anxiety: Furthermore, Kim et al. demonstrated that acupuncture at acupoint PC6 (Neiguan) alleviates chronic mild stress-induced anxiety-like behavior in rats by suppressing hypothalamic c-Fos expression [14], and our research group found that acupuncture at acupoint HT7 (Shenmen) ameliorates ethanol withdrawal-induced anxiety by normalizing amygdaloid catecholamine levels [11].