Among all virulence factors, only agrIV, agr deficiency, seb, lukF-PV/lukS-PV, hlb, adsA and tst1 showed at least a weak association with infection (p ≤ 0.2 and OR ≥ 1, Supplementary Table S2) and were included in the multivariate analysis to assess their association with SSTI. The gene discussed is RNF170; the disease is hyperinsulinemic hypoglycemia, familial, 4.