Adipokines and free fatty acids released from adipose tissue stimulate the activity of macrophages, which express the proinflammatory cytokines TNF-α and IL-6; these factors interfere with the physiological function of adipocytes and induce the development of insulin resistance in adipocytes (Klimcakova et al., 2010; Li F. et al., 2017). Here, TNF is linked to Insulin resistance.