Thus, combined pro-nociceptive and pro-inflammatory action of cytokines IL-6, IL-18, CXCL1, LIF, and MIF could occur in the trigeminovascular system, which comprises of peripheral trigeminal neurons and vessels in meninges located outside the brain blood barrier, that might explain specific migraine related changes in our patients. The gene discussed is CXCL1; the disease is migraine disorder.