CXCL1 and migraine disorder: CXCL1, like IL-6 is a pro-inflammatory and pro-nociceptive cytokine (Wang et al., 2008; Yang et al., 2016) that is co-expressed in sensory neurons together with neuropeptide CGRP (Cao et al., 2016), which is a major migraine mediator (Tfelt-Hansen and Olesen, 2011).