In a population outcome-based sub-study conducted on nearly 5000 subjects from the REGARDS Study, it has been shown that Lp-PLA2 activity above the sex-specific 80th percentile (250 U/L in males, 200 U/L in females) was associated with CHD risk over 5.3 years by Cox proportional hazards regression (30). Here, PLA2G7 is linked to coronary artery disorder.