It is possible that selective expression of IKK adaptor proteins may direct the specificity of response in this infection model; namely, upregulation of NEMO, SINTBAD and TANK without upregulation of other scaffolds such as RIOK3 and DOK3 may facilitate high expression of NF-κB target genes (Il1a, Tnf, Nos2) and type I IFN responsive genes (Ifit1/2/3, Oas1/2/3, Gbp3) while limiting overall expression of IFNα and IFNβ themselves. The gene discussed is GBP3; the disease is infection.