Interestingly, in the interferon signaling pathways, Ifnar2 and the interferon-responsive genes Cxcl11, Ifit1, Irf5 and Isg15 were verified to be upregulated during pneumonia (Supplementary Table 2), documenting that neutrophils are well able to respond to type I interferon signaling. Here, ISG15 is linked to susceptibility to pneumonia measurement.