Strikingly, 10 downregulated DE mRNAs are predicted targets of 4 or more of the upregulated DE miRs (Dip2c, Dynll2, Efnb2, Enah, Lrp2, Nfib, Sos2, Trim2, Wdr50, and Zbtb20), and several of these mRNAs act in processes that are likely to be critical in neutrophil function and host defense during infection, including gene transcription, cell migration and apoptosis (Supplementary Table 10). The gene discussed is TRIM2; the disease is infection.