Accordingly, stabilization of both HIF1 and HIF2 in a 5/6 renal ablation model of VHL–/– mice was also associated with exacerbated renal fibrosis, and treatment with YC-1, an anti-HIF-1 agent, inhibited the progression of renal fibrosis in UUO model mice7. This evidence concerns the gene VHL and renal fibrosis.