EPAS1 and chronic kidney disease: In contrast, HIF-2α activation after 2 weeks of CKD induction significantly attenuated the increases in the BUN (73.0 ± 7.5 mg/dL, P < 0.01) and Cr levels (0.63 ± 0.02 mg/dL, P < 0.05) compared to wild-type CKD mice at 4 weeks.