The mRNA expressions of VEGF 120, 164, and 188 isoforms were lower in wild-type and HIF-2α transgenic CKD mice compared to controls at 2 weeks, whereas the decrement in mRNA expressions of VEGF isoforms in wild-type CKD mice significantly increased in HIF-2α transgenic CKD mice without regard to the activation timing at 4 weeks. The gene discussed is EPAS1; the disease is chronic kidney disease.