In contrast with the inconsistent results in mRNA expressions of transgenic CKD mice at 2 weeks between total VEGF and its isoform 120, 164, and 188, which are known to play a major role on angiogenesis in the kidney24, 25, those were significantly higher in HIF-2α transgenic mice at 4 weeks of CKD induction. This evidence concerns the gene EPAS1 and chronic kidney disease.