In addition, compared to wild-type CKD mice, the protein expression of fibronectin was 1.28-fold higher at 2 weeks (P < 0.05) and 1.20-fold higher at 4 weeks (P < 0.05) in transgenic CKD mice after simultaneous CKD induction and HIF-2α activation. This evidence concerns the gene EPAS1 and chronic kidney disease.