EPAS1 and chronic kidney disease: At 2 weeks, transgenic CKD mice with HIF-2α activation from the beginning of the 0.2% adenine diet showed BUN (74.3 ± 5.6 mg/dL) and Cr levels (0.56 ± 0.05 mg/dL) comparable to those of wild-type CKD mice (Table 1).