As a proof of concept, we applied smMIPs to map part of the metabolic transcriptome of a VHL-defective ccRCC cell line and a VHL-rescued isogenic derivative, as well as in four clinical samples of clear cell renal cell cancers, with matching normal kidney tissue, and patient-derived glioma xenograft models. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.