The significant risk factors included sex, age, T2DM duration, SBP, TC, Apo A, Cr, BUN, total bilirubin, Trappin-2, IGFBP-6, BMP-4, Decorin, Siglec-5, TIMP-4 and CDH5 (Table 4). This evidence concerns the gene TIMP4 and type 2 diabetes mellitus.