Compared with CRC/Control tumors, the CRC cells showed poorer differentiation and more heterogeneity with spindle-shaped alternation (Fig. 4A and B), down-regulation of E-cadherin expression (Fig. 4C and D), and higher Ki-67 expression in CRC/EMT tumors (Fig. 4E and F). This evidence concerns the gene CDH1 and colorectal carcinoma.