In accordance with our in vitro data, survivin knockdown impaired the tumour-forming ability of TT2609-C02 cells characterized by a reduced tumour volume (Ctrl: 746.1 ± 320.2 mm3 vs. SVV KD: 98 ± 57.3 mm3; p < 0.001) and tumour weight (Ctrl: 0.337 ± 0.196 g vs. SVV KD: 0.019 ± 0.011 g; p < 0.001) when compared to control transfected cells (Fig. 2E). This evidence concerns the gene BIRC5 and neoplasm.