In addition to the overall suppression of the RTK-mediated pathways associated with cell growth and survival, the Wnt/β-catenin pathway was inhibited by AZD4547, which provides a mechanism for the stem cell population and functional changes that were induced by AZD4547 in our cell and animal models of ErbB2-overexpressing breast cancer. Here, ERBB2 is linked to breast carcinoma.