AZD4547 also inhibited MaSC and TIC populations alongside impaired self-renewal in ErbB2-overexpressing breast cancer cell lines (Fig. 2), premalignant mammary tissues from MMTV-ErbB2 mice (Figs 4, 5 and 6), and spontaneous tumors (Fig. 7). Here, ERBB2 is linked to breast carcinoma.