One of the possible explanations for this discrepancy is that Klotho−/−/VDRΔ/Δ mice on rescue diet used in the current study displayed no mineral disturbance, whereas others used Klotho−/− mice, characterised by 1,25(OH)2D3-mediated hypercalcemia and hyperphosphatemia. Here, KL is linked to hypercalcemia disease.