To determine whether the DXN can protect against the toxicity induced by Aβ1-42 expression, transgenic C. elegans smg-1 (cc546)I temperature sensitive Aβ strain CL4176 was used, and human Aβ1-42 peptide has been transferred into worms and controlled by the promoter of myo-3, thus the over expression of Aβ1-42 in the muscle cells can induce AD-like symptom of Aβ-dependent paralysis. This evidence concerns the gene SMG1 and Alzheimer disease.