rs1130214 is a G to T intronic variant upstream of the 5′UTR.31 The substitution may play a role in regulating AKT transcription as it falls within an E2F transcription factor binding site and corresponded to reduced AKT protein levels in a previous schizophrenia cohort.31 We detected no differences in total AKT protein, or phosphoprotein, between SNP rs1130214 genotypes, however AKT activity was increased in homozygous carriers of the minor allele. This evidence concerns the gene AKT1 and schizophrenia.