CDKN2A and esophageal squamous cell carcinoma: We also confirmed other frequently mutated driver genes, including NOTCH1, ZNF750, FAT1, MLL2, and CDKN2A, clustered in several ESCC-associated pathways, such as the NOTCH pathway, the Wnt pathway, cell cycle regulation, and histone modification, in dysplasia samples (Supplementary Fig. 3).